RNAimmune currently provides services to facilitate pre-clinical research needs from DNA sequence to animal study:

Facilitate your work with:

  • DNA synthesis & plasmid prep​

    • Scale: from 10µg to 10mg​

    • DNA synthesis ​

    • Assembly into E. coli-based plasmids​

    • PhD level support for basic and complex designs

  • mRNA synthesis & QC

    • ​In-vitro translation at 3 to15mg scale ​

    • licensed CleanCap™ capping agent​

    • Uridine or pseudo-uridine option​

    • Basic QC included: concentration, purity, pH and integrity ​

    • Full QC on request

  • LNP formulation & QC

    • Scale: 1mL to 1L ​

    • Systemic, local and non-hepatic delivery​

    • Mixers: microfluidic, IJM & T-mixer​

    • Post-processing: TFF, dialysis, cryo​

    • Basic QC included: pH, encapsulation, size, PDI, ζ-potential; additional QC / stability tests / development on request

  • In-vitro & In-vivo testing

    • Models: Balb/c, C57BL/6, SCID, NSG​

    • Xenografts with 4T1, CT26, LL/C, MC-38, B16-F10, and human tumor cell lines​

    • Variety of administration routes​

    • Samples: blood, sera, organs, tumors​

    • Evaluate tumor, TIL, ELISA, Western, virus-neutralizing Ab titer, Flow cytometry